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Coating

COATING

NIR spectrometers play an important role in coating processes by offering real-time monitoring, rapid analysis, and non-destructive measurements. This helps ensure the quality, uniformity, and efficiency of the tablet coating, contributing to the overall success of pharmaceutical manufacturing.


The uniformity and thickness of the coating layer play an important role for several pharmaceutical dosage forms such as controlled-release tablets, film-coated tablets, and sustained-release tablets. And coating on pellet can also be monitored.


COATING ENDPOINT DETERMINATION:

  • Brimrose NIR 7030 spectrometer can be installed in-line to determine the endpoint of the coating process. By continuously analyzing the spectra during the coating operation, the system can quantify the coating quality.
  • Laser Drilling Machines are used by pharmaceuticals to produce precision apertures in the outer coating of tablets that allow for sophisticated drug delivery with the benefits of decreased dosing frequency, consistent drug concentration and customized delivery profiles.
  • A basic laser drilling process includes lining up tablets on a conveyor, determining which side the tablet is facing, drilling the correct side of the tablet, and removing any rejected tablets for 100% accuracy. This process can drill up to 60,000 tablets per hour.
  • The Brimrose AOTF-NIR was introduced to this process to determine the integrity of the tablet coating prior to the drilling process.
  • The speed and robustness of the AOTF-NIR technology provides added quality control without any reductions to production speed and measure the presence and uniformity of coating on light and dark tablets.
  • Two spectrometers are used in tandem to inspect tablets before drilling.

A PROVEN ADVANTAGE

  • Ensures product quality
  • End point of coating process
  • Production cost savings
  • Faster Product Turnaround Time
  • Modulates drug release property
  • True Single Tablet Analysis
  • 100 Percent Accuracy
  • Extremely Fast Speed 60000 tablets/hour
  • Non-destructive Analysis Ensures the Integrity of Each Tablet for Laser Processing and Consumption

Related Products

AOTF-NIR Spectrometers

Luminar 5030 Miniature Hand-Held AOTF-NIR Analyzer

AOTF-NIR Spectrometers

Luminar 7030-IP55 Miniature Free Space Process Analyzer

Raman Spectrometers

Hyperflux™ Raman Analyzer