Bioprocess Monitoring

UPSTREAM BIOPROCESSING

• Raman spectroscopy technology emerges as a vital tool for upstream Process Analytical Technology (PAT), enabling the monitoring of Critical Quality Attributes (CQAS) in mammalian cell cultures. Tornado's Raman spectroscopy-based analyzers offer an exceptional solution for monitoring Critical Control Parameters (CCP) in CHO cell cultures for monoclonal antibody production.Their HudsonTM Bioreactor Raman Immersion Probe facilitates sterile in-line spectral acquisition, minimizing contamination risks associated with repeated sampling, and enabling in-line real-time monitoring of titer, cell counts, glucose, lactate, osmolality, ammonium, and antibody concentration.

DOWNSTREAM BIOPROCESSING

• Raman spectroscopy is emerging as a technique for real-time measurements for in-line downstream process control and monitoring.
• Tornado's HyperFlux PRO Plus is a powerful tool for monitoring downstream protein purification process quality. The HyperFlux PRO Plus equipped with HTVS technology produces highly detailed chemical information, and does so faster, with better signal-to- noise ratios and lower limits of detection. The PRO Plus can be used to establish optimal purification end points, detect process excursions with root cause determinability, enhance process understanding and control of the manufacturing process, and increase yields and profitability.

APPLICATIONS & ADVANTAGES OF RAMAN ANALYSIS