Coupled High-Throughput Raman and Ultrasonic Particle Manipulation for Increased Sensitivity and Selectivity in a Cell Reactor

High-performance Raman spectroscopy, made possible by Tornado Spectral Systems’ patented High-High-performance Raman spectroscopy, made possible by Tornado Spectral Systems’ patented High-Throughput Virtual Slit (HTVS™), increases Raman signal by delivering an order of magnitude more photons to the detector when compared to conventional spectrometers. This revolutionary improvement in spectrometer throughput and signal strength results in a three-to six-fold increase in signal-to-noise resolution, or a ten-fold decrease in exposure time requirements. This enables faster measurements, lower limits of detection, or the use of intrinsically safe lower laser power, if needed. Furthermore, additional gains in Raman spectrum quality and sensitivity can be achieved via ultrasonic manipulation of particulates in the sample matrix, as described in this white paper.